《Preparation and characterization of cyclodextrin nanosponges for organic toxic molecule removal》 was published in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2020. These research results belong to Varan, Cem; Anceschi, Anastasia; Sevli, Serhat; Bruni, Natascia; Giraudo, Leonardo; Bilgic, Elif; Korkusuz, Petek; Iskit, Alper B.; Trotta, Francesco; Bilensoy, Erem. Synthetic Route of C7H6N4O The article mentions the following:
Cyclodextrin-based nanosponges (CD-NS) are considered as safe and biocompatible systems for removing toxic mols. from the body. Rapid removal of toxic mols. that are formed in the body from certain food constituents, is relevant especially for patients affected by chronic kidney disease. Within the scope of this study, innovative cyclodextrin polymers were synthesized to form nanosponges able to remove indole, before it could form the toxic indoxyl sulfate in the body. Furthermore, in vivo studies were carried out using the two optimal CD-NS formulations by assessing physicochem. properties, stability, indole adsorption capacity and in vitro cytotoxicity. NS prepared from β-cyclodextrin crosslinked with toluene diisocyanate was found to be the most effective NS with an in vitro indole adsorption capacity of over 90%. In addition, this derivative was more stable in gastrointestinal media. Animal studies further revealed that oral CD-NSs did not tend to accumulate and damage gastrointestinal tissues and are excreted from the GI tract with minimal absorption. In conclusion, this study suggests that CD-NS formulations are effective and safe in removing toxic mols. from the body. Their potential use in veterinary or human medicine could reduce dialysis frequency and avoid hepatic and cardiac toxicity avoiding the indole formation. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Synthetic Route of C7H6N4O)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Synthetic Route of C7H6N4O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem