In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1003-21-0 as follows. Recommanded Product: 5-Bromo-1-methyl-1H-imidazole
To a solution of 153.3 (2.5g, O.76mmol, 1.Oeq) and5-bromo-1-methyl-1H-imidazole (1.5g, O.92mmol, 1.2eq) in a mixture of 1,2-dimethoxyethane (2OmL) and water (5mL), sodium carbonate (2.4g, 2.3mmol, 3.Oeq) was added. Reaction mixturewas degassed with argon for 15mm. Then [1,1?-Bi s(diphenylphosphino)ferrocene]di chloropalladium(II) complex with CH2C12 (0. 9g, 0. O7mmol, O.leq) was added and again degassed for 5mm. Reaction mixture was stirred at 115 C for 2h. After completion of the reaction, the reaction mixture was transferred into water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to obtain crude product. This was purified by column chromatography using 2% MeOH in CH2C12 to obtain pure 212.1 (1.3g, 60.50%). MS(ES): m/z 281.57 [M+H].
According to the analysis of related databases, 1003-21-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (869 pag.)WO2018/75937; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem