Iddon, Brian; Lim, Bee Lan published the artcile< Metal-halogen exchange reactions of mono- and polyhaloimidazoles>, Application In Synthesis of 1003-21-0, the main research area is exchange lithium halogen haloimidazole; haloimidazole lithiation alkylation; imidazole halo lithiation alkylation; ethoxymethylation lithiation haloimidazole; sulfuration lithiation haloimidazole; alkylhaloimidazole; methylthiophenylthioimidazole; phenylthioimidazole.
Treatment of 4(5)-bromoimidazole with 1-2 equiv BuLi in Et2O or THF followed by reaction with Me2SO4 gave 46-63% of a 1:1-3 mixture of 4- and 5-bromo-1-methylimidazole, resp. 5-Iodo- and 2,4,5-tribromo-1-methylimidazole were similarly prepared N-1-alkylation of tribromoimidazole with ClCH2OEt in C6H6 containing Et3N gave 2,4,5-tribromo-1-(ethoxymethyl)imidazole (I). Similar reaction of 2,4,5-triiodoimidazole required NaOMe in dioxane and gave mainly 1-ethoxymethyl-4,5-diiodoimidazole. Treatment of I with BuLi followed by (PhS)2 gave 67% 4,5-dibromo-1-(ethoxymethyl)-2-phenylthioimidazole, which on further treatment with BuLi followed by (MeS)2 gave 63% 4-bromo-1-(ethoxymethyl)-5-methylthio-2-phenylthioimidazole.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alkylation. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Application In Synthesis of 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem