Zhu, Mei; Dong, Biao; Zhang, Guo-Ning; Wang, Ju-Xian; Cen, Shan; Wang, Yu-Cheng published the artcile< Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands>, Reference of 452-06-2, the main research area is HIV1 protease inhibitor purine base derivative; Biological evaluation; HIV-1 protease inhibitors; Purine bases.
Introducing purine bases to P2-ligands might enhance the potency of Human Immunodeficiency Virus-1 (HIV-1) protease inhibitory because of the carbonyl and NH groups promoting the formation of extensive H-bonding interactions. In this work, thirty-three compounds are synthesized and evaluated, among which inhibitors 16a, 16f and 16j (I – III, resp.) containing N-2-(6-substituted-9H-purin-9-yl)acetamide as the P2-ligands along with 4-methoxylphenylsulfonamide as the P2′-ligand, display potent inhibitory effect on the activity of HIV-1 protease with IC50 43 nM, 42 nM and 68 nM in vitro, resp.
Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Reference of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem