Padroni, G.; Patwardhan, N. N.; Schapira, M.; Hargrove, A. E. published the artcile< Systematic analysis of the interactions driving small molecule-RNA recognition>, Synthetic Route of 452-06-2, the main research area is small mol RNA interaction therapeutic target.
RNA mols. are becoming an important target class in drug discovery. However, the principles for designing RNA-binding small mols. are yet to be fully uncovered. In this study, we examined the Protein Data Bank (PDB) to highlight privileged interactions underlying small mol.-RNA recognition. By comparing this anal. with previously determined small mol.-protein interactions, we find that RNA recognition is driven mostly by stacking and hydrogen bonding interactions, while protein recognition is instead driven by hydrophobic effects. Furthermore, we analyze patterns of interactions to highlight potential strategies to tune RNA recognition, such as stacking and cation-π interactions that favor purine and guanine recognition, and note an unexpected paucity of backbone interactions, even for cationic ligands. Collectively, this work provides further understanding of RNA-small mol. interactions that may inform the design of small mols. targeting RNA.
RSC Medicinal Chemistry published new progress about Aminoglycosides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Synthetic Route of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem