Lim, Gary N.; Ross, Ashley E. published the artcile< Purine Functional Group Type and Placement Modulate the Interaction with Carbon-Fiber Microelectrodes>, Computed Properties of 452-06-2, the main research area is purine functional group interaction carbon fiber microelectrode; adenine; adenosine; carbon-fiber microelectrode; fast-scan cyclic voltammetry; guanine; guanosine.
Purine detection in the brain with fast-scan cyclic voltammetry (FSCV) at carbon-fiber microelectrodes (CFME) has become increasingly popular over the past decade; despite the growing interest, an in-depth anal. of how purines interact with the CFME at fast-scan rates has not been studied. Here, the functional group type and placement in the purine ring modulate sensitivity, electron transfer kinetics, and adsorption on the carbon-fiber surface. Similar studies of catecholamine interaction at CFME with FSCV have informed the development of novel catecholamine-based sensors and is needed for purine-based sensors. The authors tested purine bases with either amino, carbonyl, or both functional groups substituted at different positions on the ring and an unsubstituted purine. Unsubstituted purine showed very little to no interaction with the electrode surface, indicating that functional groups are important for interaction at the CFME. Purine nucleosides and nucleotides, like adenosine, guanosine, and ATP, are most often probed using FSCV due to their rich extracellular signaling modalities in the brain. Because of this, the extent to which the ribose and triphosphate groups affect the purine-CFME interaction was also evaluated. Amino functional groups facilitated the interaction of purine analogs with CFME more than carbonyl groups, permitting strong adsorption and high surface coverage. Ribose and triphosphate groups decreased the oxidative current and slowed the interaction at the electrode which is likely due to steric effects and electrostatic repulsion. This work provides insight into the factors that affect purine-CFME interaction and conditions to consider when developing purine-targeted sensors for FSCV.
ACS Sensors published new progress about Carbon fibers Role: ARU (Analytical Role, Unclassified), BUU (Biological Use, Unclassified), PEP (Physical, Engineering or Chemical Process), TEM (Technical or Engineered Material Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses), PROC (Process). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Computed Properties of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem