Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7757-21-3, name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 7757-21-3
A solution of 4-bromo-2-iluoropyridine (17.6 mg, 0.1 mmol), (IH- benzo[d]imidazol-2~yl)methanamine HCl salt (2.6.4 mg, 0.12 mmol), cesium carbonate (0.25 mmol) in DMF (1.0 mL) was microwave irradiated at 90 C for lOmin. The solvent wras then removed under vacuum. The residue was dissolved in EtOAc (25 mL), filtered. The organic layer was washed with brine (25 mL), dried and concentrated under vacuum. Purification by chromatography afforded the N-((l H-benzo[d]imidazol-2-yl)methyl)-4-bromopyridin-2- amine.
The synthetic route of 7757-21-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF WASHINGTON; BUCKNER, Frederick, S.; ALVAREZ, Ximena, Barros; FAN, Erkang; GILLESPIE, John, Robert; HOL, Wilhelmus, G.J.; HUANG, Wenlin; KOH, Cho, Yeow; RANADE, Ranae, M.; SHIBATA, Sayaka; VERLINDE, Christophe, L.M.; ZHANG, Zhongsheng; (249 pag.)WO2016/29146; (2016); A1;,
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