Reference of 3034-50-2, A common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 33: 1 -trityl-1 H-imidazole-4-carbaldehydeTo a solution of 1W-imidazole-4-carbaldehyde {30.0 g, 0.30 mol) in DMF (200 mL) was added Et3N (70 mL, 0.375 mol) under ice bath, and then Trt-CI (105 g, 0.375 mol) was added in portions and the mixture stirred at RT overnight. The mixture was evaporated in vacuo and the residue was washed with anhydrous Et2O (4 x 50 mL), and the resulting precipitate was dried to yield the title compound (100 g, 100%) as a yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/4096; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem