Today I want to share an article with you. The article is 《DMSO as C1 Source under Metal- and Oxidant-free Conditions: NH4SCN-mediated Synthesis of Quinazolinone and Dihydroquinazolin-4(1H)-one Derivatives》,you can find this article in 《Asian Journal of Organic Chemistry》. The following contents are mentioned:
A new and efficient strategy for the development of quinazolinones I(R = iso-Pr, cyclohexyl, 4-methylphenyl, thiophen-2-ylmethyl, etc.) and dihydroquinazolin-4(1H)-ones II (R1 = Me, Ph, Bn, etc.; R2 = H, Bu, 4-chlorophenyl, pyridin-4-yl, etc.) promoted by ammonium thiocyanate is reported. Most remarkably, DMSO is used for solvent as well as methine and bridged methylene source to obtain a wide variety of new N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones II. This transformation possesses significant advantages such as metal- and oxidant-free, non-acidic medium, simple condition, good functional group tolerance and broad substrate scope. Besides, this process could be readily scaled up and applied to drug mols. synthesis. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .
2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem