Related Products of 4887-83-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4887-83-6 name is 7-Methyl-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 1 -chloro-5-fluoro-3,3,4,4-tetramethyl-isoquinoline (1 .67 mmol, 0.430 g) in pyridine (0.20 M, 9.0 mL) at room temperature was added 4-methyl-1 H-benzimidazole (1 .5 equiv., 2.69 mmol, 0.356 g) and the mixture was stirred at 90 C for 15 hours. The reaction mixture was allowed to cool down to room temperature and then concentrated under vacuo. The residue obtained was purified by flash chromatography to give 5-fluoro-3,3,4,4- tetramethyl-1 -(4-methylbenzimidazol-1 -yl)isoquinoline (0.525 g, 87% yield) as a beige solid : mp= 1 18-120C, LC-MS (Method G) UV Detection: 220 nm, Rt = 1 .19, MS: (M+1 ) = 336; 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1 .32 (s, 6 H) 1 .47 (s, 6 H) 2.71 (s, 3H) 6.91 -6.95 (m, 1 H) 7.10 – 7.25 (m, 5 H) 8.18 (s, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Methyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; BOU HAMDAN, Farhan; QUARANTA, Laura; TRAH, Stephan; WEISS, Matthias; (101 pag.)WO2016/156085; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem