Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Quality Control of 3034-50-2.
Fabra, David;Matesanz, Ana I.;Herrero, Jorge M.;Alvarez, Cristina;Balsa, Lucia M.;Leon, Ignacio E.;Quiroga, Adoracion G. research published 《 Two Different Thiosemicarbazone Tauto-Conformers Coordinate to Palladium(II). Stability and Biological Studies of the Final Complexes》, the research content is summarized as follows. Thiosemicarbazone moiety is a valuable scaffold for the synthesis of metallic complexes with anticancer purposes, when bearing N-heterocyclic the final compounds possess diverse biol. activities. Using thiazole as bioisosteres, the resulting thiosemicarbazones can afford synthetic drugs with a variety of pharmacol. effects. Trying to elucidate, if metal complexes from α-N-heterocyclic thiosemicarbazones can achieve more selectivity vs. special tumor lines, authors have developed new metal complexes with 1H-imidazole-4-carboxaldehyde 4-N-p-tolyl- and 4-N-phenylthiosemicarbazone (HL1 and HL2 resp.). The solution studies of these ligands showed a tautomeric equilibrium in solution and their reaction with Li2PdCl4 proved the stability of both forms affording two mononuclear Pd(II) complexes. Both tautomeric forms are clearly coordinated to palladium center acting as two different bidentate ligands. Palladium complexes’ stability in biol. buffers was investigated to stablish the optimal conditions for the evaluation of cytotoxicity, that on the triple neg. adenocarcinoma cell line showed IC50 values in the low micromolar range. Complexes were also studied with CT DNA (UV-Visible spectroscopy and viscosity) and with the pBR322 plasmid supercoiled models, indicating non covalent interaction.
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Quality Control of 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem