The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Quality Control of 3034-50-2.
Elumalai, Vijayaragavan;Hansen, Joern H. research published 《 A Green, Scalable, One-Minute Synthesis of Benzimidazoles》, the research content is summarized as follows. A substantially improved synthesis of 2-substituted benzimidazoles was described by condensation of 1,2-diaminoarenes and aldehydes using methanol as the reaction medium. The developed method afforded moderate to excellent yields (33-96%) at ambient temperature, displayed high functional group tolerance, was conducted open to air and required only one minute reaction time under catalyst- and additive-free conditions. Moreover, this efficient protocol permited scale-up to multi-gram scale synthesis of benzimidazoles and will become a method of choice when constructing such heterocyclic systems.
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Quality Control of 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem