These common heterocyclic compound, 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C12H12N2O2
Method Aq, Step 6:Comopund Aq6 (0.46 g) in CICH2CH2CIZMeCN (20 rnL, 1/1) was treated with PPh3-HBr (0.73 g) and heated for 5 hours before solvent was removed. The residue was taken up in THF/DMF (27.5 mL, 10/1 ) and 3-rnethoxy~4-(1-(4- methylinidazolyf))benza.de?yde (0.29 g) was added. The mixture was cooled to 0 0C and LHMDS (4.5 mL, 1.0 M in THF) was added dropwise. The mixture was stirred at 0 0C for 1 hour and then room temperature for 1 hour before NH4CI was added to quench the reaction. The residue was diluted with EtOAc. The aqueous layer was extracted with EtOAc. The organic layer was washed with water, brine, dried over MgSO4, and concentrated to give the crude product which was purified by column chromatography etuting with EtOAc/hexanes to yield compound Aq7 (0.13 g).
The synthetic route of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; ZHU, Zhaoning; GREENLEE, William J.; HUANG, Xianhai; QIN, Jun; LIU, Xiaoxiang; LI, Hongmei; ZHOU, Wei; PALANI, Anandan; ZHU, Xiaohong; VICAREL, Monica L.; MANDAL, Mihirbaran; SUN, Zhong-Yue; BENNETT, Chad E.; MCCRACKEN, Troy M.; GALLO, Gioconda; WO2010/56849; (2010); A1;,
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