Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Product Details of C4H4N2O.
Chai, Yong-Mei;Zhang, Hong-Bin;Zhang, Xiao-Yi;Chai, Lan-Qin research published 《 X-ray structures, spectroscopic, antimicrobial activity, ESP/HSA and TD/DFT calculations of Bi(III) complex containing imidazole ring》, the research content is summarized as follows. A novel complex [Bi(L)2(NO3)3] (L = 2-(4-imidazolyl)-4-methyl-1,2-dihydroquinazoline-N3-oxide) was synthesized via complexation of the quinazoline ligand L with Bi(III) nitrate pentahydrate in methanol and Et acetate. The structure of complex was determined by elemental anal., FT-IR, UV-vis and fluorescence spectroscopy, as well as characterized by X-ray crystallog. Crystallog. anal. divulged that the central atom Bi(III) was coordinated with eight atoms and the ratio of ligand-to-metal was 2:1. Specially, it fostered into an infinite 1-D chain, 2-D layered and ladder-like 3-D supramol. skeleton through different intermol. interactions. In addition, the fluorescence behaviors of Bi(III) complex in six solvents of diverse polarities were quite different. The DFT/B3LYP theor. level has been successfully applied to calculate the optimized geometry, electronic distribution of HOMO-LUMO and the electrostatic potential diagram of Bi(III) complex. Meanwhile, the electronic transitions recorded by TD/DFT calculation theor. rationalized the UV-vis spectrum data. The antibacterial activity of Bi(III) complex against Escherichia coli and Staphylococcus aureus were further studied. Plausible non-covalent interactions were quantified using Hirshfeld surfaces and 2D fingerprint plots.
Product Details of C4H4N2O, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem