Synthetic Route of 693-98-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 693-98-1 as follows.
EXAMPLE 42 2-Methyl-1-(p-nitrophenyl)imidazole A mixture of 50.0 g of p-fluoronitrobenzene, 85.93 g of 2-methylimidazole and 44.9 g of potassium carbonate in 860 ml of dimethylsulfoxide is heated at 120¡ã C. for 24 hours. The mixture is poured into 2.5 liter of water and stored in a refrigerator for two days. The mixture is filtered and cake washed with copious volumes of water and vacuum dried. The cake is dissolved in 1500 ml of ethyl acetate, filtered through hydrous magnesium silicate and the filtrate reduced to about 500 ml, cooled and the resulting solid, filtered, and air dried to give 81.0 g of the desired product as brown crystals, m.p. 135¡ã-137¡ã C.
According to the analysis of related databases, 693-98-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; American Cyanamid Company; US5128351; (1992); A;; ; Patent; American Cyanamid Company; US5077409; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem