Electric Literature of 570-22-9, These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of CoCl2¡¤6H2O (0.1 mmol, 0.0237 g), imidazole-4,5-dicarboxylate (0.1 mmol,0.0156 g), 1,4-bis(1-imidazoly)benzene (0.1 mmol, 0.0210 g), NaOH (0.2 mmol, 0.0800 g), H2O(10 mL) and DMF (2 mL) was stirred for 1 h in air, then transferred to and sealed in a 25 mLTeflon-lined reactor and heated in an oven to 110 C for 72 h. After cooling to room temperature,brown block crystals of 1 were collected by ltration and washed with water and DMFseveral times.
Statistics shows that 1H-Imidazole-4,5-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 570-22-9.
Reference:
Article; Wang, Ke-Hua; Journal of Coordination Chemistry; vol. 70; 24; (2017); p. 3982 – 3995;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem