Electric Literature of 54624-57-6, A common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2. 2-(lH-Benzoimidazol-2-yl)-3-cyclohexyl-lH-indole-6-carboxylic acid methyl ester (10.3)A reaction flask was charged with 100 mg (0.26 mmol) 10.2, 64 mg (0.33 mmol, 1.25 eq) 2-bromobenzimidazole and 15 mg (0.013 mmol, 0.05 eq) Pd(PPh3 )4. To this was added 4 mL dioxane and 1 mL NaHCO3 (sat., aq.). The reaction mixture was degassed and purged with Argon (2x), and then gently heated to 90 0C for 4 h. HPLC and LC-MS analysis confirmed complete consumption of 10.2. The reaction mixture was allowed to cool to room temperature and then concentrated. The desired methyl ester was precipitated by addition of cold H2O and collected by centrifuge. 10.3 was dried under vacuum and used without further purification. MS: 374.1 (M+H+).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GENELABS TECHNOLOGIES, INC.; WO2008/11521; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem