The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Influence of nicotinic acid homologs on oxidation of cholesterol-26-C14 by rat liver mitochondria》. Authors are Kritchevsky, David; Tepper, Shirley A..The article about the compound:3-Pyridinepropionic acidcas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1).COA of Formula: C8H9NO2. Through the article, more information about this compound (cas:3724-19-4) is conveyed.
Nicotinic acid (I) and its homolog 3-pyridylacetic acid (II) have been reported to act as hypocholesterolemic agents. I, II, and propionic (III), butyric (IV), and valeric (V) acids with ω-(3-pyridyl) substitutions, all in 8 × 10-5M concentrations were incubated for 18 hrs. in a solution (composition given) containing cholesterol-26-C14 (VI) plus a soluble cofactor and other constituents. The percentage oxidation of the VI was calculated from the C14O2 evolved by the action of rat liver mitochondria suspended in the solution Quant. data are tabulated. Some oxidation of VI occurred in the absence of I and similar compounds The I increased the oxidation of VI to a significant extent when average values for 8 experiments were determined although the results in individual experiments showed considerable variation. II was nearly as active as I in promoting the oxidation When average effects were calculated, III and V depressed the oxidation while IV had no effect. I diminishes cholesterol in the blood probably by increased oxidation together with alterations in lipid synthesis. ` For experiments in vitro, the effects of II and its higher homologs probably result from a direct oxidation of cholesterol and are not secondary to other metabolic actions of mitochondria.
The article 《Influence of nicotinic acid homologs on oxidation of cholesterol-26-C14 by rat liver mitochondria》 also mentions many details about this compound(3724-19-4)COA of Formula: C8H9NO2, you can pay attention to it, because details determine success or failure
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem