So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jiang, Min; Peng, Lei; Yang, Kai; Wang, Tianqi; Yan, Xueming; Jiang, Tao; Xu, Jianrong; Qi, Jin; Zhou, Hanbing; Qian, Niandong; Zhou, Qi; Chen, Bo; Xu, Xing; Deng, Lianfu; Yang, Chunhao researched the compound: 3-Pyridinepropionic acid( cas:3724-19-4 ).Quality Control of 3-Pyridinepropionic acid.They published the article 《Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization》 about this compound( cas:3724-19-4 ) in Journal of Medicinal Chemistry. Keywords: propanamide synthesis SAR RANKL RANK bone resorption osteoclastogenesis. We’ll tell you more about this compound (cas:3724-19-4).
Targeting RANKL/RANK offers the possibility of developing novel therapeutic approaches to treat bone metabolic diseases. Multiple efforts have been made to inhibit RANKL. For example, marketed monoclonal antibody drug Denosumab could inhibit the maturation of osteoclasts by binding to RANKL. This study is an original approach aimed at discovering small-mol. inhibitors impeding RANKL/RANK protein interaction. We identified compound 34 as a potent and selective RANKL/RANK inhibitor by performing structure-based virtual screening and hit optimization. Disruption of the RANKL/RANK interaction by 34 effectively inhibits RANKL-induced osteoclastogenesis and bone resorption. The expression of osteoclast marker genes was also suppressed by treatment of 34. Furthermore, 34 markedly blocked the NFATc1/c-fos pathway. Thus, our current work demonstrates that the chem. tractability of the difficult PPI (RANKL/RANK) target by a small-mol. compound 34 offers a potential lead compound to facilitate the development of new medications for bone-related diseases.
After consulting a lot of data, we found that this compound(3724-19-4)Quality Control of 3-Pyridinepropionic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem