The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl 2-cyanoacetate(SMILESS: O=C(OC(C)(C)C)CC#N,cas:1116-98-9) is researched.Recommanded Product: Hydrogen tetrachloroaurate(III) trihydrate. The article 《External Reductant-free Stepwise [3+2] Cycloaddition/Reductive Cyclization from 2-Nitrochalcones and Isocyanides: Synthesis of Pyrrolo[3,4-c]quinoline N-oxides》 in relation to this compound, is published in Asian Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:1116-98-9).
A novel and unprecedented route for the synthesis of pyrrolo[3,4-c]quinoline N-oxides I [R = H, Cl, Br, Me, OMe; R1 = H, Cl, Br, CF3, OMe; R2 = H, Cl, Br, Me; R3 = H, Br, Me, OMe; R4 = H, Cl, Br, Me, OMe; R3R4 = -CH=CHCH=CH-; R5 = Me, Et, t-Bu] is described. The synthetic approach involves a stepwise [3+2] cycloaddition/reductive cyclization from readily available 2-nitrochalcones 2-NO2-4-R-5-R1C6H2CH=CHC(O)(2-R2-3-R3-4-R4C6H2) and activated methylene isocyanides R5OC(O)CH2CN. The unique feature of this transformation is the reductive cyclization of C-N bond forming without any external reductants. Moreover, the application of pyrrolo[3,4-c]quinoline N-oxides I is realized to formed pyrrolo[3,4-c]quinoline derivatives II (R = R2 = H; R1 = H, Br; R3 = H; R4 = H, Me, OMe; R3R4 = -CH=CHCH=CH-; R5 = Et, t-Bu).
Here is just a brief introduction to this compound(1116-98-9)Application In Synthesis of tert-Butyl 2-cyanoacetate, more information about the compound(tert-Butyl 2-cyanoacetate) is in the article, you can click the link below.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem