Related Products of 3724-19-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity. Author is Reddy, K. Papi; Bid, Hemant K.; Nayak, V. Lakshma; Chaudhary, Preeti; Chaturvedi, J. P.; Arya, K. R.; Konwar, Rituraj; Narender, T..
The taxane diterpenoid 2-deacetoxytaxinine J (2-DAT-J; I) has been isolated from the bark of Himalayan yew, Taxus baccata L. spp. wallichiana in a reasonably good yield (0.1%) and its anticancer activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal human kidney epithelial cell line (HEK-293) has been studied. 2-DAT-J showed significant in vitro activity against breast cancer cell line at a concentration of 20 μM and 10 μM in MCF-7 and MDA-MB-231 resp. A few novel taxoids were derived from the naturally occurring 2-DAT-J and screened for their anticancer activity. The structure-activity relationship studies indicated that the cinnamoyl group on C-5 and acetyl group on C-10 are essential for the anticancer activity. 2-DAT-J was also tested for its in vivo activity on DMBA-induced mammary tumors in virgin female Sprague Dawley rats at a dose of 10 mg/kg body weight orally for 30 days and showed significant regression in mammary tumors as compared to vehicle treated group (p < 0.05). Here is a brief introduction to this compound(3724-19-4)Related Products of 3724-19-4, if you want to know about other compounds related to this compound(3724-19-4), you can read my other articles.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem