Application of 693-98-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 693-98-1, name is 2-Methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Synthesis of 2-methyl-1-aryl-1H-imidazole 5: To a stirring solution of 2-methyl- 1H-imidazole 4 (800 mg, 9.74 mmol) in 6 mL anhydrous dimethyl sulfoxide under argon was added iodobenzene (1.09 mL, 9.74 mmol), copper(I) iodide (185 mg, 0.97 mmol) and anhydrous potassium carbonate (2.69 g, 19.49 mmol). The reaction mixture was then heated to 130 C and allowed to stir for 48 hours in a sealed tube. Following completion of the reaction, the mixture was transferred to a separatory funnel containing ethyl acetate (200 mL) and the crude product was washed with water (4×40 mL) and brine (2×30 mL) before the organic layer was collected and dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo. The product was purified via flash column chromatography using hexanes :ethyl acetate (1:1 to 1:4) to elute pure 2-methyl-i -phenyl- 1H-imidazole 5 as a clear oil (730 mg, 47%). [00264] Yield: 47% yield; 730 mg of 5 was isolated as a clear oil. ?H NMR (400 MHz, CDC13): 7.51 -7.37 (m, 3H), 7.30 -7.22 (m, 2H), 6.98 (dd, J = 9.7, 1.4 Hz, 2H), 2.35 (s, 3H). ?3C NMR (100 MHz, CDC13): 144.8, 138.2, 129.6, 128.3, 127.8, 125.6, 120.8, 13.9.Note: NMR spectra match those previously reported.?
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED; HUIGENS, Robert, William; ABOUELHASSAN, Yasmeen; BASAK, Akash; (220 pag.)WO2018/106922; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem