Adding a certain compound to certain chemical reactions, such as: 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2466-76-4, Formula: C5H6N2O
General procedure: To a solution of N -acetylimidazole 7a (1 mmol) and a suitable Baylis-Hillman acetate 1 (1 mmol) in DMF (1 mL), K2CO3 (1 mmol) was added and the resulting mixture was stirred at room temperature until complete consumption of N -acetylimidazole 7a. The reaction mixture was then diluted with water (20 mL) and extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with brine and dried over anhydrous Na2SO4 . After removal of the solvent under reduced pressure, the residue was puried by flash chromatography over silica gel with EtOAc and hexane (1:1). (E)-Methyl 2-((1-imidazolyl)methyl)-3-phenylacrylate (8a) Yellow oil; yield (141 mg, 58percent); 1H NMR (500 MHz, CDCl3) : 8.03 (s, 1H), 7.48 (s, 1H), 7.42 (d, J =7.4 Hz, 3H), 7.31 (d, J = 6.8 Hz, 2H), 7.01 (s, 1H), 6.85 (s, 1H), 4.96 (s, 2H), 3.79 (s, 3H); 13C NMR (125MHz, CDCl3) : 166.9, 144.9, 137.0, 133.9, 129.7, 129.1, 129.0, 128.8, 127.0, 118.8, 52.5, 43.0; HRMS (IT-TOF); Anal. Calcd. for C14H14N2O2 : m=z 243.1128; Found [M+H]+: m=z 243.1126.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-1-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Article; Koeseceli Oezenc, Ay?en; Celik, Ilhami; Koekten, ?ule; Turkish Journal of Chemistry; vol. 41; 3; (2017); p. 323 – 334;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem