Application of 716-79-0, A common heterocyclic compound, 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, molecular formula is C13H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 28 mL of dimethyl sulfoxide was added 2.8 g (14 mmol, 1 equivalent) of 2-phenyl-1H-1,3-benzodiazole, 1.6 g (28 mmol, 2 eq.) Of potassium hydroxide, 0.12 g (0.72 mmol, 5 molpercent) of potassium iodide were sequentially added thereto, followed by cooling and stirring, 3.0 mL (28 mmol, 2 equivalents) of butane bromide was slowly added thereto, and the mixture was heated to room temperature and agitated for 4 hours. After completion of the reaction, 60 mL of water and 60 mL of ethyl acetate were added to the reaction mixture, After further washing with 60 mL of water, the solution was concentrated and purified by silica column chromatography to obtain 3.3 g (91percent) of 1-butyl-2-phenyl-1H-1,3-benzodiazole.
The synthetic route of 716-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samyang Co., Ltd.; Oh Cheon-rim; Lee Jae-hun; Kwon Jae-gwan; Lee Deuk-rak; Lee Won-jung; (17 pag.)KR2018/77354; (2018); A;,
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