Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate
(1) potassium carbonate K2CO3 , AMST-1 C12H20N2O3 , AMST-2 C33H25BrN4 , In acetonitrile is added to the reaction kettle, raising the temperature to 80 C, keeps reaction for 3 hours, HPLC monitoring reaction, after the completion of reaction of outer 95 C distilling acetonitrile, lowering the temperature to 0 C stirring 8 hours, filtration products, the filter cake is acetonitrile leaching, after drying, the crude product in water for 3 C beating 5 hours to remove the inorganic salt, filtered, washed with water, 90 C drying to constant weight to obtain the product AMST – 3 C45 H44 N6 O3 ; K the potassium carbonate2 CO3 , AMST-1 C12H20N2O3 , AMST-2 C33H25BrN4 , Acetonitrile and water mass ratio of the 173:150: 383:2000: 1600;
The synthetic route of 144689-93-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangxi Yong Tong Technology Co., Ltd.; Liu Zhongchun; (10 pag.)CN107311989; (2017); A;,
Imidazole – Wikipedia,
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