Synthetic Route of 39513-26-3, These common heterocyclic compound, 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-bromo-1,3-dihydro-2H-benzo[d]imidazol-2-one (50 mg, 0.235 mmol), 20 (124 mg, 0.352 mmol), and Pd(PPh3)4 (14mg, 5 mol%), were combined in a microwave vial and flushed with N2 for5 min. Dioxane (3 mL) and aq. K3PO4 (1 M, 0.5 mL) wereadded and the mixture was heated in a Biotage microwave at 100 C for 1 h. H2O(3 mL) and EtOAc (7 mL) were added and the organic layer was separated, driedusing Na2SO4 and evaporated. Gilson HPLC purificationafforded 22 (1.44 mg, 2%).
The synthetic route of 39513-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lotesta, Stephen D.; Marcus, Andrew P.; Zheng, Yajun; Leftheris, Katerina; Noto, Paul B.; Meng, Shi; Kandpal, Geeta; Chen, Guozhou; Zhou, Jing; McKeever, Brian; Bukhtiyarov, Yuri; Zhao, Yi; Lala, Deepak S.; Singh, Suresh B.; McGeehan, Gerard M.; Bioorganic and Medicinal Chemistry; vol. 24; 6; (2016); p. 1384 – 1391;,
Imidazole – Wikipedia,
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