Synthetic Route of 53981-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53981-69-4 name is 1-(1H-Imidazol-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 6-bromo-3-(bromomethyl)-l,2-benzoxazole (55 mg) in acetonitrile (0.9 mL) were added potassium carbonate (78 mg) and l-(lH-imidazol-2-yl)ethanone (22 mg). After stirring for 2 hours at 80 C, the reaction was filtered and the filtrate was concentrated in vacuo. The residue was purified with OH-type silica gel column chromatography (5-60 % EtOAc in n-hexane) to give the title compound (54 mg, 89 % yield) as colorless solid. MS (ESI) m/z : 320[M+l] RT = 0.936 min. LCMS Condition : B.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-2-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem