Application of 10597-52-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10597-52-1 name is 7-Nitro-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step B: Preparation of tert-butyl 4-nitro-1H-benzo[d]imidazole-1-carboxylate: Triethylamine (1.03 mL, 7.36 mmol) was added to a suspension of 4-nitro-1H-benzo[d]imidazole (1.0 g, 6.13 mmol) in dichloromethane (50 mL), followed by addition of Boc2O (1.61 g, 7.36 mmol). The reaction was stirred at room temperature for 16 hours and then quenched with water (20 mL). The aqueous layer was extracted with dichloromethane (50 mL*3), and the combined organics were dried, filtered and concentrated. The crude product was purified by flash column chromatography, eluding with hexanes/ethyl acetate (4:1) to give the desired product (1.50 g, 93%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Nitro-1H-benzo[d]imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Array Biopharma, Inc.; US2010/63066; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem