Application of 288-32-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-32-4, name is 1H-Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 1 N-(Triphenylmethyl)imidazole (2) A stirred suspension of triphenylmethanol (2.6 g, 10 mmol) and 1.36 g (20 mmol) of imidazole in 10 mL of HOAc was heated to 100° C. under N2 for 1 h. The cooled mixture was diluted with Et2 O and washed with water, saturated Na2 CO3, water (until neutral), brine, dried (MgSO4), filtered and concentrated. The crude product was purified by flash chromatography (110 g SiO2, 25percent-50percent EtOAc-hexanes) to give 0.78 g (25percent) of a solid. This was recrystallized from EtOAc to give 0.20 g of (2), m.p. 221°-223° C. IR (KBr) 1489, 1443, 1210, 1072, 750, 701, 662 cm-1. NMR (CDCl3): d 6.82, 7.07, 7.47 (all t, J=1, imidazole CH); 7.14 (m, 6H); 7.32 (m, 9H). Anal. Calc’d (C22 H18 N2): C, 85.13; H, 5.84; N, 9.03. Found: 85.16; 5.87; 9.02.
The synthetic route of 1H-Imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Alcon Laboratories, Inc.; US6051573; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem