Synthetic Route of 52099-72-6,Some common heterocyclic compound, 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound III-1 (1.74 g, 10 mmol) represented by the following structural formulaPotassium carbonate (2.74 g), 1,4-dibromopropane (6.07 g, 30 mmol) was added to a solution of (20 ml) in DMF for 3 hours,Stir at 60 C. Water was added to the reaction solution, and extracted with ethyl acetate.The organic layer was washed with brine and dried over Na 2 SO 4. Filtration,After evaporation of the solvent, the residue is subjected to silica gel column chromatographyPurification by (AcOEt / n-hexane 1: 4) gave compound III-2 (1.961 g, 66%) as a colorless oil.
The synthetic route of 52099-72-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tokyo Medical and Dental University; Hata, Yutaka; Kagechika, Hiroyuki; Ito, Shigeru; Tsuemoto, Nozomi; kodaka, Manami; Dilihumaer, Ainiwaer; (24 pag.)JP2019/89720; (2019); A;,
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