Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(1H-Imidazol-2-yl)ethanone
To a mixture of l-(l /-imidazol-2-yl) ethan-l-one (32 mg, 0.290 mmol) and 2-(4- formylphenyl)-N-(perfluorophenyl) acetamide (124 mg, 0.377 mmol, 1.3 eq) in a microwave vial under nitrogen were added piperidine (61 mu, 0.726 mmol, 2.5 eq) and anhydrous methanol (5.0 mL) via syringe. The reaction mixture was heated in the microwave synthesizer for 5 h and it was monitored by TLC (50% ethyl acetate/hexanes). Methanol was removed on a rotary evaporator to obtain a brown oil. It was chromatographed by preparative TLC in 50-75% ethyl acetate /hexanes to obtain (£)-2-(4-(3-(l /-imidazol-2-yl)-3-oxoprop- l-en-l-yl) phenyl)-N-(perfluorophenyl) acetamide 35 as a brown solid (16 mg, 13.07%). TLC R/ = 0.5 (50% ethyl acetate/hexanes), mp 235 C. NMR (600 MHz, CD3OD) delta 7.94 (s, 1H), 7.92 (s, 2H), 7.89 (s, 2H), 7.86 (s, 1H), 7.75 (d, J = 8.1 Hz, 6H), 7.46 (d, J = 8.0 Hz, 6H), 7.41 (s, 3H), 7.29 (s, 3H), 3.83 (s, 7H). 13C NMR (151 MHz, MeOD) delta 178.61, 170.86, 166.79, 145.98, 140.81, 137.75, 133.73,130.15,129.59,128.66 ,121.42120.82,41.70 ppm. HRMS calcd for C20H14F5N3O2 :423.10 found: 423.1146
The synthetic route of 53981-69-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY OF TOLEDO; TILLEKERATNE, Viranga; AL-HAMASHI, Ayad; DLAMINI, Samkeliso; ALQAHTANI, Abdulateef, Saeed; KARAJ, Endri; (69 pag.)WO2019/36607; (2019); A1;,
Imidazole – Wikipedia,
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