In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53710-78-4 as follows. Product Details of 53710-78-4
General procedure: 60% NaH (0.23 mmol) was added to a solution of 6a (0.23 mmol) in dry DMF (15 mL) at 0-5C. After stirring for 15 min at room temperature. 1-(3-chloropropyl)-1H-imidazole or 1-(4-chlorobutyl)-1H-imidazole (0.34 mmol) was added and stirred for 12 h at 60-65 C. After cooling, the mixture was poured into H2O (120 mL) and the resulting solution was extracted with ethyl acetate (60 mL × 3). The organic phase was combined, washed with brine (180 mL× 3), dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel using petroleum ether/ethyl acetate/MeOH (5:10:1, v/v) as eluent to afford 7d or 7e.
According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Hu, Yuanyuan; Ruan, Wenchen; Gao, Anhui; Zhou, Yubo; Gao, Lixin; Xu, Meng; Gao, Jianrong; Ye, Qing; Li, Jia; Pang, Tao; Pharmazie; vol. 72; 12; (2017); p. 707 – 713;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem