Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., name: 1H-Imidazole
Step 1 1H-Imidazole (10 g, 147 mmol) was dissolved in THF (150 mL). Dimethylsulfamoyl chloride (19 g, 132 mmol) was added followed by the dropwise addition of triethylamine (20 g, 198 mmol). The mixture was stirred at room temperature overnight. The mixture was poured into H2O (200 mL) and extracted with EtOAc three times. The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo to give crude N,N-dimethyl-1H-imidazole-1-sulfonamide (27 g) that was used without further purification.
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KALYPSYS, INC.; US2009/62253; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem