Electric Literature of 53981-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53981-69-4 name is 1-(1H-Imidazol-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To an ice coled solution of 1-(1H-imidazol-2-yl)ethanone (2.0 g) in MeOH (36 mL) was added NaBH4 (0.69 g). After stirring for 30 minutes at 0C, the reaction mixture was concentrated in vacuo. The residue was purified with amino-type silica gel column chromatography (0- 10 % MeOH in CHCb) to give the title compound (lntermediate-3, 1.9g, 96 % yield) as colorless solid. -NMR data of Intermediate -3 is shown in Table 1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-2-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem