Synthetic Route of 41716-18-1,Some common heterocyclic compound, 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-Methyl-4-imidazolecarboxylic acid (4-1) (265 mg, 2.1 mmol)Was dissolved with N, N-dimethylformamide (12 mL)N-Methylmorpholine (850 mg, 8.4 mmol) was added with stirring,The reaction solution was placed in an ice water bath and slowly stirred for 10 minutes,Trimethylacetyl chloride (277 mg, 2.3 mmol) was then slowly added dropwise,Complete addition the reaction was stirred for 30 minutes under ice-water bath maintained;After the anhydride is completely formed,Under ice-cooling, a solution of 1- (4-methoxyphenyl) -3-methyl-2-piperazinone hydrochloride (4 -2) (462 mg, 1.8 mmol)Plus,The reaction was stirred at room temperature for 1 hour, followed by monitoring the reaction; After the reaction was completed, quenched with water, the reaction was concentrated in vacuo, the concentrate was extracted with dichloromethane, and then washed with saturated brine, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure.The concentrate was subjected to column chromatography to obtain a white solid1- (4-methoxyphenyl) -3-methyl-4- (1-methyl- 4- carbonylimidazole) piperazin- 2-one (compound- 4),Yield 70percent,
The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fujian Jinle Pharmaceutical Technology Co., Ltd.; Zhou Zhongxiang; Xing Yuanyuan; Chen Yingzhong; Deng Chengjun; Deng Honggui; Xue Wanhua; Zhang Shuzu; Chen Weipeng; Li Fang; (27 pag.)CN107174584; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem