5395-50-6, name is 1,3,4,6-Tetrakis(hydroxymethyl)tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1,3,4,6-Tetrakis(hydroxymethyl)tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
In a 50 mL flask equipped with a thermometer, 1.31 g (5.0 mmol) of 1,3,4,6-tetrakis (hydroxymethyl) glycoluril,Pyridine 3.90 g (50.0 mmol)And 25 mL of N, N-dimethylformamide.To the resulting mixture was added, under ice cooling,After 5.33 g (50.0 mmol) of methacryloyl chloride was added dropwise,And the mixture was stirred overnight at room temperature.After this,100 mL of water was added to the obtained reaction mixture,Extraction operation was carried out with 100 mL of ethyl acetate.The obtained organic layer was concentrated under reduced pressure,The obtained concentrate was purified by silica gel chromatography (ethyl acetate / hexane = 1/1 (volume ratio)),733 mg of 1,3,4,6-tetrakis (methacryloyloxymethyl) glycoluril was obtained as a colorless liquid.Yield 27%.
The synthetic route of 5395-50-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHIKOKU CHEMICALS CORPORATION; KUMANO, TAKESHI; TAKEDA, TAKUMA; MIZOBE, NOBORU; (9 pag.)JP2015/57375; (2015); A;,
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