A common compound: 120781-02-4, name is Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 120781-02-4
[0277] In a microwave tube was placed N,N-bis(4-methoxybenzyl)-4-((3-phenyl-1H- pyrazol-4-yl)methyl)benzenesulfonamide (138 mg, 0.25 mmol), methyl 2-bromo-i-methyl- 1 H-imidazole-5-carboxylate (54.8 mg, 0.25 mmol), (1 S,2S)-Ni ,N2-dimethylcyclohexane- 1,2- diamine (14.22 mg, 0.100 mmol), Cul (9.52 mg, 0.050 mmol), and Phosphoric acid, potassium salt (159 mg, 0.750 mmol). The air was removed and re-filled with N2 (3 times). Then Toluene (2 ml) was added and the mixture was stirred at 110 C for overnight. After cooling to rt, the mixture was dilute with EtOAc (3 mL) and filtered through celite and eluted with EtOAc. The filtrate was concentrated and the mixture was purified by silica gel chromatography using 10-25% EtOAc/hexane as the eluent to give methyl 2-(4-(4-(N,N- bis(4-methoxybenzyl)sulfamoyl)benzyl)-3 -phenyl- 1 H-pyrazol- 1 -yl)- i-methyl- 1H-imidazole- 5-carboxylate (57 mg, 0.082 mmol, 33.0 % yield). MS (M+H) = 692.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 120781-02-4, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; MALONEY, David J.; JADHAV, Ajit; BANTUKALLU, Ganesha Rai; BRIMACOMBE, Kyle Ryan; MOTT, Bryan T.; YANG, Shyh Ming; URBAN, Daniel Jason; HU, Xin; SIMEONOV, Anton; KOUZNETSOVA, Jennifer L.; WATERSON, Alex Gregory; SULIKOWSKI, Gary Allen; KIM, Kwangho; CHRISTOV, Plamen; JANA, Somnath; (387 pag.)WO2016/109559; (2016); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem