Adding a certain compound to certain chemical reactions, such as: 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 716-79-0, name: 2-Phenyl-1H-benzo[d]imidazole
Example 18 Preparation of Methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate (S18) To a suspension of 2-phenyl benzimidazole (0.32 g, 1.6 mmol) in acetonitrile (5 mL) was added caesium carbonate (0.80 g, 2.5 mmol) and methyl bromoacetate (0.16 mL, 1.7 mmol). The reaction mixture was stirred at room temperature for 3 hours and concentrated in vacuo. The residue was suspended in a mixture of CH2Cl2 and sat. NaHCO3 (vol percent 50:50, 15 mL). The aqueous layer was reextracted with CH2Cl2 (2 x 20 mL). The combined organic layers were dried over Na2SO4, filtered and concentrated in in vacuo to afford the product (0.40 g, 1.5 mmol, 91 percent). 1H NMR (400 MHz, DMSO-d6) delta 7.77 – 7.63 (m, 3H), 7.63 – 7.44 (m, 4H), 7.33 – 7.09 (m, 2H), 5.21 (s, 2H), 3.64 (s, 3H). 13C NMR (101 MHz, DMSO-d6) delta 169.40, 153.91, 143.08, 136.91, 130.57, 130.51, 129.62, 129.53, 123.45, 123.00, 119.87, 111.36, 53.17, 46.57. LC-MS (ESI): calcd for C16H14N2O2: 267.11280 [M+H]+, found: 267.18 [M+H]+; HR-MS found 267.11311 [M+H]+.
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Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Waldmann, Herbert; Triola, Gemma; Wittinghofer, Alfred; Shehab, Ismail; Bastiaens, Philippe; Vartak, Nachiket; Papke, Bjoern; Zimmermann, Gunther; EP2698367; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem