Some common heterocyclic compound, 872-82-2, name is 2-(1H-Imidazol-5-yl)ethanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-(1H-Imidazol-5-yl)ethanol
In an ice bath, add slowly to the 4-hydroxyethyl imidazole obtained in Step 1.3 mL of thionyl chloride.After the addition was complete, the mixture was warmed to room temperature and stirred to give a yellow solution.Raise the temperature to 70 C for 1 h.The brown clear solution was removed by rotary evaporation to remove the remaining thionyl chloride to give a brown viscous liquid.Add a small amount of water to dissolve,The pH was adjusted to basic with aqueous sodium carbonate solution and extracted three times with ethyl acetate.The combined organic phases are dried over anhydrous sodium sulfate.Concentrated yellow oily liquid.The crude product is separated by column chromatography.Concentrated 1.3 g of a yellow oily solution was used directly for the next reaction.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 872-82-2, its application will become more common.
Reference:
Patent; Tongwei Co., Ltd.; Zhao Yan; Zhi Yonggang; Zhang Fengping; Cao Jun; Liu Yaomin; Long Yuande; (9 pag.)CN105367500; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem