Some common heterocyclic compound, 147403-65-4, name is Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, molecular formula is C25H24N4O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C25H24N4O4
10.0 g (22.5 mmol) of Intermediate II was added to 100 ml of 1,4-dioxane, heated to reflux,A solution of 3.84 g (23.7 mmol, 1.05 eq) of carbonyldiimidazole in 50 ml of 1,4-dioxane was slowly added dropwise,After completion of the dropwise addition, the reaction was refluxed for 5 hours; the reaction was stopped and the solvent was distilled off under reduced pressure;The residue was dissolved in ethyl acetate and added with water. Under stirring, HCl was adjusted to pH 3, allowed to stand for delamination,The aqueous phase was removed; water was added for washing, the aqueous phase was separated off and the organic phase was washed with saturated brine,The aqueous phase was removed and the organic phase was cooled with an ice-water bath to cool and crystallize for 1 hour, filtered, washed with a small amount of ethyl acetate,Impurity A was obtained in a yield of 85%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 147403-65-4, its application will become more common.
Reference:
Patent; Shandong Xinhua Pharmaceutical Co., Ltd.; Wu Hui; Zheng Zhonghui; Wang Jun; Shen Hong; Xu Ling; (6 pag.)CN105924400; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem