Synthetic Route of 312-73-2, A common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a methanolic solution (5 mL) of complex 1 (0.5 g, 1.259 mmol) was added dropwise methanolic solution (5 mL) of phen (0.250 g, 1.26 mmol) and the reaction mixture was refluxed at 60 C for 5 h. The reaction mixture yielded a solid product (green coloured) which was isolated, washed with diethyl ether and methanol in portion and dried in vacuum.
The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tabassum, Sartaj; Amir, Samira; Arjmand, Farukh; Pettinari, Claudio; Marchetti, Fabio; Masciocchi, Norberto; Lupidi, Giulio; Pettinari, Riccardo; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 216 – 232;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem