Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5955-72-6, name is 2-Chloro-6-nitro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Chloro-6-nitro-1H-benzo[d]imidazole
Dimethylamine (2M in THF, 15 ml_) was added to a sealable tube containing 2-chloro-5- nitro-1 H-benzo[d]imidazole (1 g, Example 181 (a)). The reaction flask was sealed and heated at 80 C for 16 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to afford the crude title product as a black tar (800 mg). This was used directly without purification. LCMS m/z 207.16 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; DUFFY, Kevin J.; GRAYBILL, Todd L.; MOORE, Michael Lee; NEIPP, Christopher E.; RALPH, Jeffrey M.; SQUIRE, Michael Damien; (304 pag.)WO2017/153952; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem