Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-39-1, name is 2-Mercaptobenzimidazole, A new synthetic method of this compound is introduced below., Quality Control of 2-Mercaptobenzimidazole
a. A mixture of 0.46 g (0.0016 mol) of benzyl acetate 6, 0.25 g (0.0016 mol) of 1,3-dihydrobenzimidazole-2-thione, 3 mL of acetone, and 3 mL of formic acid was heated at 40C for 6 h. The reaction mixture was cooled down to ambient temperature and poured into aqueous NaCl. The precipitate that formed was filtered off, washed with water, and dried in air. Yield 0.56 g (92%), mp 168-170C (benzene). 1H NMR spectrum (CDCl3), delta,ppm: 1.34 s (18H, CMe3), 4.73 s (2H, CH2N), 5.23 s(1H, OH), 7.17 s (2H, ArH), 7.23-7.30 m (2H, H5,6),7.71-7.78 m (2H, H4,7). Found, %: C 71.45; H 7.83; N 7.27. C22H28N2OS. Calculated, %: C 71.70; H 7.66; N 7.60. b. A solution of benzyl acetate 6 and 1,3-dihydrobenzimidazole-2-thione in a 1 : 1 mixture of acetone and formic acid at ambient temperature for 2 days to obtain 98% of compound 12.
The synthetic route of 583-39-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tagasheva; Gataullina; Zaripova; Bukharov; Nugumanova; Deberdeev; Voronina, Yu. K.; Russian Journal of General Chemistry; vol. 87; 1; (2017); p. 22 – 28; Zh. Obshch. Khim.; vol. 87; 1; (2017); p. 26 – 32,7;,
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