The important role of 26663-77-4

The synthetic route of Methyl benzimidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 26663-77-4, name is Methyl benzimidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl benzimidazole-5-carboxylate

The benzimidazole -5 – methyl formate (2.66 g, 15 . 12 mmol) is dissolved in 35 ml ethanol, adding hydrazine hydrate (8.6 ml, 120.9 mmol), 80 C reflux reaction for 36 hours, filtering, to obtain white solid, then the beating of ethyl acetate three times (3 × 15 ml), to obtain 1.8 g of white solid, yield 67.7%

The synthetic route of Methyl benzimidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Wang Xiaojian; Sun Chenbin; Ge Jun; Xi Meiyang; Xiao Qiong; Yin Dali; (51 pag.)CN107151220; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem