Related Products of 16042-25-4,Some common heterocyclic compound, 16042-25-4, name is 2-Imidazolecarboxylic acid, molecular formula is C4H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The imidazole-2-carboxylic acid (10 g, 89.2 mmol) in suspension in thionyl chloride (160 mL) was heated to reflux, under agitation for 18 h. The reaction mixture was cooled, then filtered, washed with toluene, and dried under high vacuum to obtain a yellow solid (yield, 80-85%). M.p.: 164 C. 1H NMR (300 MHz, DMSO-d6) delta: 8.85 (s, 2H); 8.2 (s, 2H). 13C NMR (300 MHz, DMSO-d6) delta: 145.85, 144.95, 125.20, 120.15.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Imidazolecarboxylic acid, its application will become more common.
Reference:
Article; Moarbess, Georges; Guichou, Jean-Francois; Paniagua-Gayraud, Stephanie; Chouchou, Adrien; Marcadet, Olivier; Leroy, Fiona; Ruedas, Remi; Cuq, Pierre; Deleuze-Masquefa, Carine; Bonnet, Pierre-Antoine; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 268 – 274;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem