496-46-8, name is Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: imidazoles-derivatives
Preparation of a cucurbituril trimer (Figure 23, Compound 38) :; As is exemplified in Figure 23, an exemplary pathway for forming a cucurbituril trimer involves a disubstituted cucurbituril derived from benzil. Such a pathway generally includes preparation of a benzil-derived glycoluril, as described hereinabove, a formation OF A DERIVATIZED CB monomer, and a trimerization step. As a starting material, a benzil-derived glycoluril (Figure 23, Compound 35) is prepared by reacting a para-substituted benzil with urea in a 1: 2 ratio in benzene and trifluoroacetic acid, according to the exemplary syntheses are presented hereinabove. In one non-limiting example, one of the para-substituents on the benzil is a carboxyl group and the second is hydrogen (Figure 23, Compound 34). Compound 35, is reacted with glycoluril, Compound 2, in a 1: 5 ratio, and with formaldehyde, in the presence of concentrated sulfuric acid, to thereby form the derivatized cucurbituril biphenyl-CB [6] (Figure 23, Compound 36). Compound 36 is reacted with 1,3, 5-benzenetriamine (BTA) in a 3: 1 ratio so as to form three amide bonds between each of the carboxyl groups on the derivatized CB [6] and an amine on the BTA, and thus form a cucurbituril trimer having a BTA as the assembling unit (Figure 23, Compound 38).
The synthetic route of 496-46-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.; WO2005/23816; (2005); A2;,
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