Synthetic Route of 17325-26-7, These common heterocyclic compound, 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a) Methyl 2-isopropyl- lH-imidazole-4-carboxylateA solution of methyl lH-imidazole-4-carboxylate (5.0 g, 39.68 mmol), AgN03 (4.0 g, 23.81 mmol), isobutyric acid (10.4 g, 1 19.1 mmol) in 10 % H2S04 (150 ml) was heated at 80 C for 15 min. An aqueous solution of (NH4)2S208 (28.0 g, 119.1 mmol) was added to the mixture dropwise in 15 minat 80 C. The reaction mixture was cooled to RT and poured into ice. The mixture was basified with aqueous ammonia (pH 9) and extracted with EtOAc (500 ml). The organic layer was concentrated and the residue was purified by flash chromatography. Yield 1.5 g. 1H- NMR (400 MHz; CDC13): delta 1.36 (d, 6H), 3.05-3.14 (m, 1H), 3.87 (s, 3H), 7.62 (s, 1H).
The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORION CORPORATION; TOeRMAeKANGAS, Olli; WOHLFAHRT, Gerd; SALO, Harri; RAMASUBRAMANIAN, Rathna, Durga; PATRA, Pranab, Kumar; MARTIN, Arputharaj, Ebenezer; HEIKKINEN, Terhi; VESALAINEN, Anniina; MOILANEN, Anu; KARJALAINEN, Arja; WO2012/143599; (2012); A1;,
Imidazole – Wikipedia,
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