Application of 28890-99-5, A common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, molecular formula is C13H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 4-1 (3 g, 5.8 mmol), benzimidazolo[1,2-a]benzimidazole (1.26 g, 6.1 mmol), and potassium phosphate (2.58 g, 12.2 mmol) were suspended in NMP (29 mL). The mixture was stirred at 190 Cfor48 h. After the reaction mixture was cooled at room temperature, 58 mL of EtCH and 29 mL of water were added to the reaction mixture to give a solid. Itwas collected by filtration, and it was purifed by column chromatography on silica gel eluting with a mixed solvent of toluene and CHCI3. Then, the product was recrystallized with toluene and heptane. The formed solid was collected by filtration and dried in vacuum to yield 2.39 g (59%) of compound (B-25) as a white solid. LC-MS (mlz) 704.1HNMR (300 MHz, DMSC-d6): 68.39-8.36 (m, 2H), 8.15-8.12 (m,1H), 8.01-7.72 (m, 9H),7.61-7.25 (m, 13H), 7.01(d, J= 1.4 Hz, 1H), 7.54 (td, J= 7.5, 1.2 Hz, 1H), 6.57 (td, J= 7.5,1.2 Hz, 1H)
The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; NISHIMAE, Yuichi; KOHLSTEDT, Julia; SCHAeFER, Thomas; NAGASHIMA, Hideaki; (114 pag.)WO2016/97983; (2016); A1;,
Imidazole – Wikipedia,
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