In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7189-69-7 as follows. Recommanded Product: 7189-69-7
To a solution of phenethylamine (34, 0.15mmol) in THF (5mL), triethylamine (0.15mmol) was added. To this mixture, 1,1′-sulfonyldiimidazole (0.15mmol) was added and the reaction mixture was stirred at 60C for 2h. After the completion of the reaction monitored by TLC, water was added and the reaction mixture was extracted using ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum. The obtained intermediate 36 was used for next step without further purification. In the next step, 3-phenylpropylamine (0.15mmol) was dissolved in THF and triethylamine (0.15mmol) was added. To this mixture, 36 was added. The reaction was stirred at 60C for 3h. The reaction was monitored by TLC. After the completion of the reaction, the reaction mixture was quenched with water and the whole mixture was extracted using ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude mixture was purified by column chromatography to afford the pure product 3. Yield 72%, Pale yellow solid. Rf 0.30 (2: 1 Ethylacetate: Hexane), mp. 135-137C; IR (neat): 3362, 2950, 2822, 1560, 1523, 1345, 1170, 945cm-1. 1H NMR (CDCl3) delta 1.79-1.87 (m, 2H), 2.64 (t, J=8.00Hz, 2H), 2.85 (t, J=7.20Hz, 2H), 2.92-2.97 (m, 2H), 3.28-3.33 (m, 2H), 4.07-4.13 (m, 2H), 7.15-7.33 (m, 10H); 13C NMR (CDCl3) delta 31.13, 32.94, 35.81, 42.68, 44.31, 126.35, 127.04, 128.50, 128.71, 128.97, 128.98, 138.10, 141.04. HRMS Calcd for C17H22N2O2S m/z [M+H] 319.1481, found 319.1507.
According to the analysis of related databases, 7189-69-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Manickam, Manoj; Jalani, Hitesh B.; Pillaiyar, Thanigaimalai; Sharma, Niti; Boggu, Pulla Reddy; Venkateswararao, Eeda; Lee, You-Jung; Jeon, Eun-Seok; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 134; (2017); p. 379 – 391;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem