A new synthetic route of 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 152628-02-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 3 2-cyano-4?-(2?-n-propyl-4?-methyl-6?-(1??-methylbenzimidazol-2??-yl)benzimidazol-1?-ylmethyl) biphenyl [0023] In a 2 litre reaction flask 500 ml of methyl isobutyl ketone was added followed by 100 gm of 2-n-propyl-4-methyl-6-(1?-methylbenzimidazol-2?-yl)benzimidazole. The reaction mass was stirred and a solution of 40 gm sodium hydroxide in 300 ml water was added. To this solution, 10 gm tetra butyl ammonium hydrogen sulphate and 80 gm of 4-chloromethyl-2?-cyanobiphenyl was added. The reaction mass was warmed to 80 C. and maintained for 4 hours at 80 to 85 C. [0024] The completion of the reaction was monitored by TLC using mobile phase chloroform: methanol (9:1). After completion of the reaction, the mass was cooled to 20 C., maintained 3 hours at 15 to 20 C. The product which precipitated out was filtered, washed with methyl isobutyl ketone, followed by water to yield 126 gm of 2-cyano-4?-(2?-n-propyl-4?-methyl-6?-(1??-methylbenzimidazol-2??-yl)benzimidazol-1?-ylmethyl) biphenyl, melting at 196-198 C. [0025] C 80.53%, H 5.70%, N 14.20%; m/z=496.64 1H NMR DMSO d6 400 Mhz: delta ppm 0.96-0.99 (t, 3H) 1.75-1.84 (m, 2H) 2.62 (s, 3H) 2.89-2.93 (t, 2H) 3.80 (s, 3H) 5.67 (s, 2H) 7.18-7.92 (m, 14H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Amarnath, U; Suryakiran, U; US2015/197495; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem